The Role of Soluble Costimulatory Molecules as the Biomarkers for Aging Predictors

This study aimed to determine the role of soluble costimulatory molecules in aging and association with presence comorbid aged individuals. Thirty-two elderly twenty healthy subjects were included this study. The sCD28, sCD80, sCD86, sCD163, sCTLA4 measured using ELISA. was documented from medical records. Charlson Comorbidity Index (CCI) evaluate survival/mortality risk for subjects. levels majority significantly increased participants, while level sCD86 comparable. There weak positive correlations between subject's age sCD28 (R=0.214, p=0.048), (R=0.238, p=0.041), sCD80 (R=0.317, p=0.012). discovered be best predict immune AUC 0.71 [0.57-0.86], sensitivity 53,1%, specificity 80.0%, cut off 129ng/ml. Most participants had at least one comorbid, which approximately 25.0% 3.1% classified as mild moderate CCI. Multivariate analysis showed that comorbidities individuals have been associated ≥26.5ng/ml ≥129.0ng/ml. Furthermore, (CCI ≥1) ≥129.0ng/ml (OR 12.44 [95% CI 1.32–117.03], p=0.027). Considering these results, sCTLA4, can developed biomarkers predicting comorbidities, respectively.